Fig. 3: Grey matter atrophy in resveratrol (RSV) mouse lemurs evaluated from voxel-based morphometric analysis of serial magnetic resonance (MR) images.
a, b At initial imaging time, i.e., after approximately 3.5 years of treatment, grey matter volumes were almost similar in most brain regions of CTL and RSV animals except a very focal lower grey matter volume in the primary motor cortex in CTL animals as seen on a surface rendering and (b)coronal section (voxel-based morphometric analysis, p < 0.005, n = 5 for CTL and n = 11 for RSV animals). c–h Longitudinal follow-up of animals thereafter revealed a widely distributed age-associated grey matter atrophy in (f–h) RSV mouse lemurs and a more focal atrophy in c–e CTL animals. Coloured spots display regions with statistically significant age-related atrophy obtained (p < 0.005, n = 7 for CTL and n = 11 for RSV animals). Unlike CTL animals, RSV individuals displayed atrophy in the amygdala as well as in Brodmann areas 13-16, 1-3 (primary somato-sensorial area), and to a lower extent in area 24 (anterior cingulate cortex). Colour bars represent the value of the t-statistic (no unit). Numbers represent the Brodmann area of mouse lemur brain according to Brodmann and Le Gros Clark classification37,38. Am amygdala, Hypt hypothalamus, Se septum. Sections refer to antero-posterior coordinates.
