Fig. 1: Physiological stress hallmarks of limited bedding and nesting (LBN). | Communications Biology

Fig. 1: Physiological stress hallmarks of limited bedding and nesting (LBN).

From: Sex-specific fear acquisition following early life stress is linked to amygdala and hippocampal purine and glutamate metabolism

Fig. 1

A Experimental timeline for non-stressed (NS) controls and limited bedding and nesting (LBN) stressed mice on fear conditioning. B Significant decrease in body weight was observed after LBN exposure at P09 for females (Wx = 80, p < 0.0001), and males (T(20) = 3.13, p = 0.005). C During adult age (3 months) the body weight was significantly reduced in females (T(18) = 4.16, p = 0.0006), but not in males (T(20) = 0.88, p = 0.39). D The relative adrenal weight was not altered in females (Wx = 45, p = 0.70), but was significantly increased in LBN males (T(20) = −3.3, p = 0.003). E At P09, CORT levels were significantly elevated in LBN females (Wx = 4, p = 0.05), whereas this was not the case for males (Wx = 31, p = 0.74). F At adult age, the CORT levels were not altered by stress for both females (T(18) = 0.26, p = 0.79) and males (T(20) = 0.64, p = 0.53). The bar graphs are presented as mean ± standard error of the mean and all individual samples as points. Panels B-D, F represent female NS (n = 10), female LBN (n = 10), male NS (n = 11), male LBN (n = 11). Panel E represent female NS (n = 6), female LBN (n = 5), male NS (n = 7), male LBN (n = 10).

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