Fig. 8: Suppression of SjRho significantly decreased worm burden and liver egg deposition in mice infected with S. japonicum. | Communications Biology

Fig. 8: Suppression of SjRho significantly decreased worm burden and liver egg deposition in mice infected with S. japonicum.

From: Schistosoma sex-biased microRNAs regulate ovarian development and egg production by targeting Wnt signaling pathway

Fig. 8

a Diagram showing the schedule for siRNA administration in mice. Each group contains 6 mice (n = 6). b RT-qPCR analysis of SjRho mRNA in worms isolated from the infected mice injected with SjRho siRNA; Effect of SjRho siRNA injection on the worm burden in mice at 28 days post-infection; Effect of SjRho siRNA suppression on egg deposition in the liver of mice. Data are shown as the mean ± standard error from 6 mice (n = 6), *** P ≤ 0.001. c Histopathological analysis of liver tissues from the mice treated with PBS, control siRNA and SjRho siRNA. Arrows indicate egg-induced granuloma formation. Scale bar = 100 µm.

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