Fig. 7: CAR-T cells armored with CA2 DRD regulatable IL12 show ACZ dependent efficacy. | Communications Biology

Fig. 7: CAR-T cells armored with CA2 DRD regulatable IL12 show ACZ dependent efficacy.

From: Carbonic anhydrase 2-derived drug-responsive domain regulates membrane-bound cytokine expression and function in engineered T cells

Fig. 7

a Time course of the subcutaneous Raji model. b Mean tumor volumes of mice throughout the study (N = 7, lines connect the means). c Percent survival of mice from all groups. d Ex-vivo analysis of mbIL12 levels on the surface of CAR+ cells on day 7, 14 and 21 for DRD-regulated mbIL12-armored T cells in the no ACZ group (light pink) and the ACZ group (dark pink). e Quantitation of IL12 levels in the plasma of mice on day 7, 14, 21 and 28. f Number of CAR-T cells/mL of blood in various groups on days 7, 14, 21 and 28. Survival statistics analyzed in GraphPad Prism using Mantel-Cox test. P-values reported for data in (d, e), are from an unpaired T-Test.

Back to article page