Fig. 3: Candidate genes involved in AD-GID pairs predicted from bulk eQTLs demonstrate pleiotropic effects.
From: An atlas of the shared genetic architecture between atopic and gastrointestinal diseases
A dot plot showing the significant causal genes identified by SMR, using bulk eQTL analysis from different tissues (FDRsmr <0.05). Blue diamond-shaped dots represent negative effect size estimated from SMR while red dots represent positive relationships. B, C Representative examples of locus zoom plots. X-axis indicated the genomic positions and Y-axis indicated the –log (10) P-values representing the significance of GWAS of diseases and eQTLs. SC sigmoid colon, TC transverse colon, EGJ gastro-esophageal junction, EMa esophagea mucosa, Ems esophagus muscularis.
