Fig. 4: Disease-associated genetic loci converge on specific cell types across different tissues.
From: An atlas of the shared genetic architecture between atopic and gastrointestinal diseases
The CELLECT method was used to associate SNPs derived from GWAS summaries with 178 different cell types from four tissues (lung, airway, colon and terminal ileum). Panels A–E demonstrate representative examples of shared cell type (T cells, B cells, NK cells, monocytes) enrichments across asthma, AOA, COA, hay fever, allergy, CD, UC and celiac disease in PBMCs and lung, airway and gut tissues (colon and terminal ileum). Red color indicated the significance at FDR  < 0.05 level while yellow indicates a more lenient threshold with nominal P < 0.05. Full summaries are presented in Supplementary Figs. 2–8 and Supplementary Data 6.
