Fig. 5: Integrated scRNA-seq and bulk RNA-seq analysis revealed that microglial SMEK1 deficiency suppresses mitochondrial oxidative phosphorylation. | Communications Biology

Fig. 5: Integrated scRNA-seq and bulk RNA-seq analysis revealed that microglial SMEK1 deficiency suppresses mitochondrial oxidative phosphorylation.

From: Therapeutic potential of microglial SMEK1 in regulating H3K9 lactylation in cerebral ischemia-reperfusion

Fig. 5

A Heatmap from RNA sequencing analysis depicting genes differentially expressed between shNC-treated and shSMEK1-treated BV2 cells. B A total of 594 upregulated and 515 downregulated genes were identified using RNA sequencing analysis of shNC and shSMEK1 BV2 cells, and the expression of PDK3 was upregulated in shSMEK1 BV2 cells. C A number of cytokine-related biological processes and several biological processes related to lipid synthesis were enriched according to the GOBP analysis. GSEA of enriched fatty acid metabolism (D) and pyruvate metabolism (E).

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