Fig. 2: HFHS improves lipid and glucose metabolism in tumors and increases the expression of disruptors of energy balance. | Communications Biology

Fig. 2: HFHS improves lipid and glucose metabolism in tumors and increases the expression of disruptors of energy balance.

From: Dietary caloric input and tumor growth accelerate senescence and modulate liver and adipose tissue crosstalk

Fig. 2

A Fatty acid binding protein 3 (Fab3p) expression. B Cluster of differentiation 36 (Cd36) mRNA expression. C Expression of carnitine palmitoyltransferase 1A (Cpt1a). D Expression of peroxisome proliferator-activated receptor alpha (Ppara). E–G Tumor glycolytic metabolism evaluated by hexokinase (HK) activity (E), phosphofructokinase (PFK) activity (F), and pyruvate kinase (PK) activity (G). H Lactate dehydrogenase (LDH) activity. I Intratumor lactate levels. J Expression of parathyroid hormone-like hormone (Pthlh). K Expression of insulin-like growth factor binding protein 3 (Igfbp3). *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001. For all panels, a one-way ANOVA was performed, followed by Tukey’s post-test.

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