Fig. 1: Schematic representation of the experimental approach for identifying kinase and phosphatase inhibitors targeting the TDP-43 C-terminus self-assembly in the cytoplasm. | Communications Biology

Fig. 1: Schematic representation of the experimental approach for identifying kinase and phosphatase inhibitors targeting the TDP-43 C-terminus self-assembly in the cytoplasm.

From: TDP-43 nuclear retention is antagonized by hypo-phosphorylation of its C-terminus in the cytoplasm

Fig. 1

a Schematic representation of TDP-43 hyper- or hypo-phosphomimetic mutants. b Description of the MT bench technology which is designed to probe the mixing between wild-type and mutant TDP-43 along microtubules in HeLa cells co-expressing the indicated protein fusions. Scale bar: 20 μm. c Automatic detection of single-cell fluorescence via an automatic HCS imager in 96-well plates for measuring the mixing/de-mixing between two proteins along the microtubule network. Scale bar: 100 μm. Zoom scale bar: 50 μm. This panel was created in BioRender. Rattenbach, R. (2025) https://BioRender.com/r85f184.

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