Table 2 Antimicrobial effects of compounds 1–4

From: Engineering a promiscuous prenyltransferase for selective biosynthesis of an undescribed bioactive cannabinoid analog

Microorganism

EC50 (µM)

1

2

3

4

OA

CKa

S. aureus

24.21 ± 2.95

4.93 ± 0.70

9.62 ± 1.45

0.87 ± 0.14

NA

0.48 ± 0.05

B. subtilis

12.50 ± 1.17

2.62 ± 0.14

5.34 ± 0.56

2.08 ± 0.12

NA

0.21 ± 0.03

M. luteus

35.13 ± 3.78

8.85 ± 0.50

17.62 ± 1.36

3.16 ± 0.42

NA

0.27 ± 0.03

E. coli

NA

NA

NA

NA

NA

0.15 ± 0.02

T. rubrum

NA

NA

NA

NA

NA

3.38 ± 0.76

  1. a The positive control for S. aureus, B. subtilis and M. luteus was ampicillin sodium. The positive control for E. coli was cefotaxime sodium, and the positive control for T. rubrum was terbinafine hydrochloride.