Table 1 Significant novel loci associated with SHS with a lead variant at least 500 kb from any of the previously published genome-wide significant sleep variants

From: Genome-wide association analysis of composite sleep health scores in 413,904 individuals

SHS	Loc.	SNP	Chr.	Position (GRCh37)	Nearest gene(s)	Alleles (E/A)	EAF	INFO	BETA	SE	P
ADD	1	rs75607302	4	159677732	PPID/FNIP2	A/AT	0.428	0.977	−0.013	0.002	2.8E − 09
	2	rs10808575	8	130062388	AC068570.1/LINC00977	T/C	0.733	0.997	0.014	0.002	2.8E − 09
	3	rs12257317	10	19457469	UBE2V2P1/MALRD1	A/G	0.685	0.997	0.013	0.002	5.7E − 09
	4	rs7924036	10	65191645	JMJD1C	G/T	0.497	1.000	−0.012	0.002	7.4E − 09
	5	rs72896891	18	42632654	SETBP1	A/T	0.833	0.993	−0.018	0.003	6.8E − 10
PC1	6	rs12759956	1	18432831	RP11-174G17.2/IGSF21	T/A	0.713	0.995	0.017	0.003	4.0E − 10
	7	rs12470733	2	200968215	C2orf47/SPATS2L	C/A	0.798	0.993	−0.019	0.003	4.6E − 10
	8	rs1571582	9	103663962	RP11-394D2.1/ RP11-62L10.1	T/C	0.498	0.997	−0.016	0.002	3.4E − 11
	9	rs201449027	12	9142784	KLRG1/RP11-259O18.4	TG/T	0.561	0.965	0.016	0.002	1.4E − 10
	10	rs4559781	13	28303803	NPM1P4/GSX1	C/T	0.153	0.994	0.020	0.003	2.1E − 09
	11	rs139221256	15	85357857	ZNF592/ALPK3	T/TA	0.749	0.991	0.016	0.003	5.8E − 09
	12	rs12601771	17	4108822	ANKFY1	G/A	0.433	0.995	0.015	0.002	5.6E − 10
	13	rs8074498^a	17	79954544	ASPSCR1	T/A	0.418	0.983	0.016	0.002	1.2E − 10
	14	rs9610500	22	22221167	MAPK1	A/G	0.634	0.983	−0.015	0.003	4.8E − 09
PC2	15	rs2821226	1	203517292	OPTC/ATP2B4	A/G	0.473	0.984	−0.013	0.002	5.2E − 09
	16	rs17559978	7	84677860	SEMA3D	G/A	0.688	0.990	0.015	0.002	2.3E − 10
	17	rs11111069	12	102271962	DRAM1	C/G	0.791	0.995	−0.016	0.003	2.4E − 09
	18	rs113851179	16	1733479	LA16c-431H6.6/HN1L	C/CT	0.925	0.987	0.026	0.004	8.6E − 10
	19	rs12979056	19	17862131	FCHO1	G/A	0.542	0.992	−0.014	0.002	1.5E − 09
	20	rs3788337	22	23412017	RTDR1	G/A	0.647	0.993	−0.014	0.002	6.5E − 09
PC3	21	rs56049037	7	32947201	AVL9	G/A	0.713	0.988	0.016	0.002	1.3E − 11
	22	8:11053467-GA:G	8	11053467	XKR6	GA/G	0.555	0.914	0.014	0.002	1.6E − 09
	23	rs11494758	12	9116542	KLRG1	C/T	0.622	0.997	−0.014	0.002	3.4E − 10
	24	rs71272625	15	78166843	LINGO1/CSPG4P13	C/CT	0.331	0.931	0.014	0.002	8.8E − 10
	25	rs11373181	22	42705672	TCF20	A/AC	0.482	0.990	−0.013	0.002	3.6E − 10
PC4	26	13:58551593-GA:G	13	58551593	PCDH17/RNA5SP30	GA/G	0.763	0.993	−0.016	0.002	2.4E − 11
PC5	27	rs138572890^b	16	50264953	PAPD5	C/CTTTA	0.929	0.968	0.023	0.004	7.7E − 10
	28	19:59007970-CA:C	19	59007970	SLC27A5	CA/C	0.366	0.948	−0.013	0.002	7.0E − 11

The significance threshold was adjusted for multiple testing across six traits (p < 8.3 × 10⁻⁹).
Loc. locus, Chr. chromosome, E/A effect and alternative alleles, EAF effect allele frequency, INFO imputation quality score.
^aMissense variant.
^b3′ UTR variant.

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Table 1 Significant novel loci associated with SHS with a lead variant at least 500 kb from any of the previously published genome-wide significant sleep variants

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