Table 2 Novel SHS Polygenic Risk Score (SHS-PRS) associations in independent studies

From: Genome-wide association analysis of composite sleep health scores in 413,904 individuals

 

SHS-ADD

SHS-PC1

SHS-PC2

SHS-PC3

SHS-PC4

SHS-PC5

Study

Phenotype

Phe -code

Na

Beta (SE)/

OR (95% CI)

P‡

Beta (SE)/

OR (95% CI)

P‡

Beta (SE)/

OR (95% CI)

P‡

Beta (SE)/

OR (95% CI)

P‡

Beta (SE)/

OR (95% CI))

P‡

Beta (SE)/

OR (95% CI)

P‡

HCHS/SOL

Corresponding SHSb

 

11,144

0.063 (0.010)

3.86 E − 10

0.086 (0.009)

9.22 E − 20

0.082 (0.009)

3.86 E − 18

0.024 (0.009)

1.16 E − 02

0.047 (0.009)

5.41 E − 07

0.094 (0.009)

3.04 E − 23

MGB biobank

Insomnia

327.4

5748/30226

0.91 (0.88, 0.94)

5.87 E − 10

0.9 (0.87, 0.92)

1.15 E − 12

0.99 (0.96, 1.02)

0.416

0.97 (0.94, 1)

0.026

1.01 (0.98, 1.04)

0.372

0.96 (0.93, 0.98)

0.002

Obstructive sleep apnea

327.32

6722/30226

0.86 (0.84, 0.88)

6.73 E − 25

0.93 (0.9, 0.95)

7.65 E − 08

0.86 (0.84, 0.89)

3.88 E − 26

1.00 (0.97, 1.03)

0.998

1.08 (1.06, 1.11)

5.21 E − 09

0.94 (0.92, 0.97)

1.82 E − 05

Restless legs syndrome

327.71

1281/30226

0.86 (0.81, 0.91)

3.06 E − 07

0.86 (0.81, 0.91)

1.94 E − 07

0.93 (0.88, 0.99)

0.015

0.96 (0.91, 1.02)

0.179

1.00 (0.94, 1.06)

0.982

0.91 (0.86, 0.97)

0.002

Sleep disorders

327

3048/30226

0.88 (0.85, 0.92)

1.30 E − 09

0.9 (0.87, 0.94)

2.80 E − 07

0.94 (0.91, 0.98)

0.003

0.96 (0.93, 1)

0.053

1.01 (0.97, 1.05)

0.564

0.98 (0.94, 1.02)

0.239

Organic or persistent insomnia

327.41

1343/30226

0.87 (0.82, 0.92)

2.10 E − 06

0.87 (0.82, 0.92)

3.27 E − 06

0.97 (0.92, 1.03)

0.325

0.98 (0.93, 1.03)

0.419

1.02 (0.96, 1.08)

0.530

0.93 (0.88, 0.98)

0.008

Sleep apnea

327.3

4161/30226

0.85 (0.82, 0.88)

1.06 E − 19

0.93 (0.9, 0.96)

2.61 E − 05

0.84 (0.81, 0.87)

2.03 E − 23

0.99 (0.95, 1.02)

0.403

1.07 (1.04, 1.11)

3.84 E − 05

0.93 (0.9, 0.97)

6.77 E − 05

Sleep-related movement disorders

327.7

445/30226

0.9 (0.81, 0.99)

0.036

0.89 (0.81, 0.99)

0.024

0.99 (0.89, 1.08)

0.763

0.95 (0.86, 1.04)

0.252

1.01 (0.92, 1.11)

0.782

0.99 (0.9, 1.09)

0.774

Circadian rhythm sleep disorder

327.6

302/30226

0.85 (0.76, 0.96)

0.010

0.88 (0.78, 0.99)

0.033

0.88 (0.78, 0.99)

0.034

0.94 (0.83, 1.05)

0.246

0.97 (0.86, 1.08)

0.559

0.99 (0.88, 1.11)

0.882

Parasomnia

327.5

497/30226

0.94 (0.85, 1.03)

0.171

0.92 (0.83, 1)

0.061

0.99 (0.9, 1.09)

0.842

0.95 (0.87, 1.04)

0.277

1.01 (0.93, 1.11)

0.784

1.01 (0.93, 1.11)

0.771

Hypersomnia

327.1

989/30226

0.89 (0.84, 0.96)

0.001

0.94 (0.88, 1)

0.064

0.9 (0.84, 0.96)

0.001

0.94 (0.88, 1)

0.049

1.02 (0.96, 1.09)

0.554

0.92 (0.87, 0.99)

0.017

Central/nonobstructive sleep apnea

327.31

555/30226

0.91 (0.83, 1)

0.046

1.06 (0.97, 1.15)

0.232

0.93 (0.85, 1.01)

0.089

0.96 (0.89, 1.05)

0.407

1.07 (0.98, 1.16)

0.117

0.88 (0.8, 0.96)

0.003

Sleep-related leg cramps

327.72

223/30226

1.00 (0.86, 1.15)

0.949

0.95 (0.83, 1.1)

0.511

1.04 (0.91, 1.19)

0.563

1.07 (0.94, 1.22)

0.318

1.07 (0.94, 1.22)

0.305

1.00 (0.87, 1.14)

0.990

Cataplexy and narcolepsy

347

325/30860

0.88 (0.78, 0.99)

0.032

0.97 (0.86, 1.08)

0.558

0.88 (0.79, 0.98)

0.025

0.98 (0.88, 1.09)

0.660

1.01 (0.91, 1.13)

0.842

0.96 (0.86, 1.07)

0.432

  1. aTotal sample size is provided for continuous outcome in HCHS/SOL, sample sizes in cases vs controls are provided for binary sleep phenotypes in MGB biobank.
  2. bSHS in HCHS/SOL were calculated from the SHS-ADD definition and UKB SHS-PC loadings.
  3. ‡Significant P-values of PRS associations with corresponding SHS in HCHS/SOL accounting for 6 SHS traits (P < 0.008) and with sleep phecode in MGB biobank accounting for the number of phecode and SHS traits (P < 0.0006) shown in bold.
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