Fig. 3: Cortical projections of structural connectivity gradients and their associations to functional connectivity and structural covariance.

A Structural Connectivity (sc). (i) Sc matrix and Pearson correlation of sc profiles of each parcel (schematically displayed for 2 parcels) with the principal structural connectivity gradient (G1_sc). (ii) Projection of r values resulting from parcel-wise correlation between sc profiles and G1_sc onto the cortex. Thus, negative values (blue) indicate relation with the medial part of the thalamus, whereas positive values (red) indicate relation with lateral thalamic portions. Decoding of cortical pattern leveraging functional communities (ordered along mean). (iii) Analog parcel-wise correlation between sc profiles and secondary structural connectivity gradient (G2_sc). B Functional Connectivity (fc). (i) Fc matrix and Pearson correlation of resting state fc strength of each parcel (schematically displayed for 2 parcels) with G1_sc. (ii) Projection of r values resulting from parcel-wise correlation between fc profiles and G1_sc onto the cortex, and decoding of cortical pattern leveraging functional communities (ordered along mean). (iii) Analog parcel-wise correlation between fc profiles and G2_sc. C Structural Covariance (scov). (i) Scov matrix and Pearson correlation of thalamocortical scov of each parcel (schematically displayed for 2 parcels) with G1_sc. (ii) Projection of r values resulting from parcel-wise correlation between scov profiles and G1_sc onto the cortex, and decoding of cortical pattern leveraging functional communities (ordered along mean). (iii) Analog parcel-wise correlation between scov profiles and G2_sc. Results shown are at group-level (N = 50). Violin plots represent kernel density estimates of the data. The boxes indicate the interquartile range (25th to 75th percentile), the white dots represent the median, and the whiskers extend to 1.5 times the interquartile range. FPN Frontoparietal Network, DMN Default Mode Network.