Fig. 1: Optineurin (OPTN) is downregulated in the damaged cartilage of patients with osteoarthritis.
From: Fasting activates optineurin-mediated mitophagy in chondrocytes to protect against osteoarthritis
a Representative immunohistochemical staining of images of normal and damaged cartilage tissues isolated from patients with OA (n = 17). b OPTN expression level in knee joint cartilage tissues obtained from patients with OA; n = 17; Data represent the mean ± standard error of means (SEM), ***p < 0.001, unpaired t-test. c Three-dimensional reconstruction images of the tibial plateau from patients with OA analyzed using micro-computed tomography. Left: Normal side; Right: Damaged side; Top: Coronal plane; Bottom: Transection. Statistical analysis of bone parameters, including d bone volume fraction (Tb.BV/TV), e trabecular thickness (Tb.Th), f trabecular number (Tb.N), and g trabecular separation (Tb.Sp) in normal and damaged cartilage tissue samples isolated from patients with OA quantified using CTAn v1.9 software. Data represent the mean ± SEM, *p < 0.05, **p < 0.01, ***p < 0.001.
