Fig. 4: Depletion of OPTN results in chondrocyte apoptosis caused by impaired mitophagy.
From: Fasting activates optineurin-mediated mitophagy in chondrocytes to protect against osteoarthritis
Representative images show increased a senescence-associated β-galactosidase (SA-β-gal), b Caspase3 staining in chondrocytes from Optn-knockout (Optn−/−) mice, c Flow cytometry and Annexin V/PI staining show cell apoptosis of chondrocytes. d, e Statistical analysis of the quantified results of images in (a, b). Data represent the mean ± SEM (unpaired t-test, *p < 0.05, ***p < 0.001; n = 10 and 6 in (a, b), respectively).
