Fig. 7: Schematic illustration demonstrating fasting alleviates osteoarthritis by activating OPTN-mediated mitophagy.
From: Fasting activates optineurin-mediated mitophagy in chondrocytes to protect against osteoarthritis
Defects in the autophagy receptor OPTN in chondrocytes lead to insufficient mitophagy, accumulation of damaged mitochondria, and chondrocyte apoptosis, which are important causes of articular cartilage damage. Fasting alleviates the occurrence of osteoarthritis by activating OPTN-mediated mitophagy.
