Fig. 5: Results of meta-proteome analysis.
From: Zika virus modulates human fibroblasts to enhance transmission success in a controlled lab-setting
a Scheme of the performed meta-proteome analysis comprising 12 studies applying mass spectrometry-based analysis on human cells infected with ZIKV resulting in a dataset with more than 10,000 proteins (entries) affected by ZIKV. b Enrichment of KEGG pathways (FDR ≤ 10-4) among affected proteins classified as enzymes (top 20, ranked by enrichment factors). c The meta-proteome analysis was screened for enzymes potentially involved in the synthesis of VOCs, which were subsequently annotated with related KEGG pathways. Enzymes related to different KEGG pathways are depicted grey boxes or white boxes, if not related to any KEGG pathway. The colour of labelling represents ZIKA-induced changes observed in the meta-proteomics analysis (red: increased expression, blue: reduced expression, black: interaction, see table S5). KEGG pathways related to more than one enzyme are depicted in yellow or green boxes, depending on the number of KEGG pathway relationships.
