Fig. 4: Activity profiles of E3 ubiquitin ligases and histone acetyltransferases from ubiquitinome and acetylome data.
From: A computational tool to infer enzyme activity using post-translational modification profiling data
a Heatmap illustrating the activity profiles of E3 ubiquitin ligases across cells subjected to no stress, heat stress, or arsenite stress, with and without proteasome inhibition (0.5 μM bortezomib), as indicated by previously generated ubiquitinomic data. b Heatmap of five E3 ligases exhibiting altered activities across five stress conditions. c Heatmap depicting consistent expression level changes in three substrates of the TRIP12 ligase. d Heatmap representing the activities of histone acetyltransferases in various conditions.
