Fig. 3: Enterotypes were relevant to shrimp health.

a A subset including 165 diseased shrimp (98 WFS shrimp and 67 HPNS shrimp with clinical and histological symptom) was chosen to evaluate the relationship between enterotype and host health. b A random forests model was conducted to predict the probability of disease for WFS or HPNS. POD values were significantly different among three enterotypes (ANOVA, P < 0.01**). c The molecular ecology networks of different enterotypes, which showed that ET V and ET S hold higher average connectivity and lower average path lengths than ET CB. d Relationship between POD and abundance of the three keystone genera. POD value was significantly correlated with ratio of Vibrio/Candidatus Bacilloplasma, while POD value decreased as Shewanella increased. e The ratio Vibrio/Candidatus Bacilloplasma could effectively discriminate shrimp enterotype at dimension 1 of PCoA. f The ratio Vibrio/Candidatus Bacilloplasma was negatively correlated to Chao1 index and Shannon index.