Fig. 2: Exploration of parameter space and Functional Connectivity Dynamics (FCD) corresponding to the optimal model parameters.
From: Transient destabilization of whole brain dynamics induced by N,N-Dimethyltryptamine (DMT)
A Normalized Euclidean distance between simulated and empirical FCD averaged across n = 50 simulations for every pair of parameters λ and β. The matrices reveal different peak amplitude (λ) and latency (β) values for placebo vs. DMT. Optimal performance for DMT is restricted to a narrower region. The red stars indicate the optimal pair of parameters selected for each condition. B Empirical and optimal simulated FCD (columns) for the placebo and DMT conditions (rows) averaged over n = 15 subjects (independent simulations). Simulated FCD matrices were computed using optimal λ and β parameters marked with the red stars in the left panel. Euclidean distances between simulated and empirical FCDs were 0.19 ± 0.03 and 0.14 ± 0.02 (95% confidence interval [CI]) for DMT and placebo respectively (FCD: functional connectivity dynamics; DMT: dimethyltryptamine).
