Fig. 4: Time-dependent effect of simulated perturbations indicate higher reactivity for DMT vs. placebo.
From: Transient destabilization of whole brain dynamics induced by N,N-Dimethyltryptamine (DMT)
A Reactivity \(\chi (t)\) normalized by the number of nodes in the corresponding RSN, for placebo (top) and DMT (bottom). DMT curves peak around 4 minutes after the dose, restoring baseline values at the end of the session. Placebo shows a lower peak amplitude and longer latencies remaining constant during the whole study. Shaded regions of each line denote the standard deviation of the reactivities (n = 25 simulations). B Plots of the peak \(\chi (t)\) across time (\({\chi }_{\max }\)) for each RSN and three different external perturbation intensities (\({F}_{{ext}}\)) (n = 200 bootstrapped samples). Comparisons between conditions (for a given perturbation intensity) and between successive perturbation intensities (for a given condition) were made with two-sided t-tests, giving p-values < 0.0001 for all comparisons. Executive control (EC) network was an exception when comparing \({F}_{{ext}}\,\)= 0.005 and \({F}_{{ext}}\,\)= 0.01 (p = 0.23) (DMT: dimethyltryptamine; RSN: resting state network).
