Fig. 5: The peak differential reactivity to external perturbations (Δχmax) between DMT and placebo correlates with the local 5HT2a receptor density.
From: Transient destabilization of whole brain dynamics induced by N,N-Dimethyltryptamine (DMT)
A Spatial configuration of the six RSN that constrained the simulated delivery of the perturbation (Vis: primary visual, nVis = 7; ES: extrastriate, nES = 9; Aud: auditory, nAud = 26; SM: sensorimotor, nSM = 13; DM: default mode, nDM = 12; EC: executive control, nEC = 24), adapted from Ipiña, I. P. et al.40. B 5HT2a receptor density per RSN (individual points and mean \(\pm \,\)SE). C Peak of \(\Delta \chi (t)\) (n = 200), \({\Delta \chi }_{\max }\), vs. the 5HT2a receptor density of each RSN together with the best least-squares linear fit. The inset shows the distribution of correlation coefficients (\(\rho\)) obtained using a bootstrap procedure (ncorr = 1000). D Correlation coefficient \(\rho\) (mean \(\pm \,\)SD) vs. the external perturbation intensity, \({F}_{{ext}}\), n = 1000. (DMT: dimethyltryptamine; RSN: resting state network; 5HT: 5-hydroxytryptamine).
