Fig. 10: Proposed regulatory network for carbon catabolite repression (CCR) and de-repression (CCDR) in Magnaporthe oryzae. | Communications Biology

Fig. 10: Proposed regulatory network for carbon catabolite repression (CCR) and de-repression (CCDR) in Magnaporthe oryzae.

From: A multilayered regulatory network mediated by protein phosphatase 4 controls carbon catabolite repression and de-repression in Magnaporthe oryzae

Fig. 10

During CCR (glucose as a carbon source), phosphorylated Snf1 and Smek1 regulate the phosphorylation states of CreA and Crf1, activating CreA and inactivating Crf1, thereby repressing non-preferred carbon source catabolism genes. Under CCDR conditions (l-arabinose as the carbon source), Snf1 phosphorylates Pp4c, which dephosphorylates CreA and Crf1, resulting in CreA inactivation and Crf1 activation to promote expression of non-preferred carbon source catabolism genes. Sak1 and Tos3 are kinases activating Snf1. The catalytic subunit of the protein phosphatase that catalyzes CreA dephosphorylation when glucose is the carbon source has not been identified.

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