Fig. 3: Effect of bambuterol after treatment with AβO in a primary culture of hippocampal neurons on synapses. | Communications Biology

Fig. 3: Effect of bambuterol after treatment with AβO in a primary culture of hippocampal neurons on synapses.

From: Evidence from a mouse model supports repurposing an anti-asthmatic drug, bambuterol, against Alzheimer’s disease by administration through an intranasal route

Fig. 3

A Effect of bambuterol (green) on total number of synapses. Donepezil (DPZ) served as a positive control (blue). Results are expressed as mean ± SEM [n = 6 except for Aβ (n = 5), bambuterol 1 nM (n = 5), bambuterol 1 μM (n = 5) and donepezil 1 μM (n = 5)] as a percentage of control (control (white) = 261 ± 8 PSD95 + /Synaptophysin+ synapses/field). *p < 0.05 vs. AβO condition (red) (one-way ANOVA followed by PLSD Fisher’s test). B Representative images of synaptophysin (red) and PSD95 (green) staining of rat primary hippocampal neurons in the presence of vehicle (negative control), AβO (20 µM), bambuterol (10 nM) and donepezil (1 µM).

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