Fig. 5: Effects of a formulation of bambuterol on locomotor activity and anxiety in mice in the open-field test. | Communications Biology

Fig. 5: Effects of a formulation of bambuterol on locomotor activity and anxiety in mice in the open-field test.

From: Evidence from a mouse model supports repurposing an anti-asthmatic drug, bambuterol, against Alzheimer’s disease by administration through an intranasal route

Fig. 5

Effects of a chronic intranasal administration of bambuterol-loaded liposomes, embedded in a thermogelling formulation (green), on the total distance traveled during free exploration in the open field on day 17 after surgery (A), and on time spent away from center (marker of anxiety) at open field on day 17 after surgery (B). Results are expressed as mean ± SEM [n = 12 except for control (n = 11) and Aβ (n = 11)]. One-way ANOVA followed by Fisher’s LSD test. *p < 0.05 vs. Aβ1-42 (red) was considered significant. Control: white.

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