Fig. 7: Effect of formulated bambuterol on the neuronal survival. | Communications Biology

Fig. 7: Effect of formulated bambuterol on the neuronal survival.

From: Evidence from a mouse model supports repurposing an anti-asthmatic drug, bambuterol, against Alzheimer’s disease by administration through an intranasal route

Fig. 7

Effect of formulated bambuterol (green) on the neuronal survival (NeuN) in the CA1 area of the hippocampus. Results are expressed as mean ± SEM [n = 6 except for Aβ (n = 4)]. (control (white) = 109 ± 3 Neun+ cells/field). One-way ANOVA followed by Fisher’s LSD test. *p < 0.05 vs. Aβ1-42 was considered significant (red). B Representative images of NeuN staining of rat primary hippocampal neurons after treatment with vehicle, Aβ1-42 oligomers, and Aβ1-42 oligomers + bambuterol (300 µg/kg/day).

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