Fig. 4: The induced-fit recognition between the ribozyme and SARS-CoV-2 RNA.
From: A hammerhead ribozyme selects mechanically stable conformations for catalysis against viral RNA
a The setup of the single-molecule induced-fit experiments. b The distribution of extension changes upon unfolding the ribozyme in the presence of the RNA sequence of SARS-CoV-2 and magnesium ions. N = 235 from 125 ribozyme molecules. c The corresponding unfolding force distributions for (b). Left, 99; right, 136 data points. d The distribution of extension changes upon unfolding the ribozyme in the presence of substrate RNA without magnesium ions. N = 133 from 85 ribozyme molecules. e The corresponding unfolding force distributions for (d). Left, 78; right, 55 data points.
