Fig. 4: Effect of different carbon sources on BDQ-induced growth inhibition rescue by ASCT expression. | Communications Biology

Fig. 4: Effect of different carbon sources on BDQ-induced growth inhibition rescue by ASCT expression.

From: Development of tolerance to bedaquiline by overexpression of trypanosomal acetate: succinate CoA transferase in Mycobacterium smegmatis

Fig. 4

The effects of ASCT on transgenic M. smegmatis treated with various concentrations of BDQ were investigated by culturing cells in minimal media (HdeB) supplemented with various carbon sources: 22.5 mM malate, 30 mM glycerol, 45 mM acetate, 22.5 mM succinate, or 15 mM glucose. Asterisks indicate statistically significant differences (p ≤ 0.05, Welch’s t-test) in ASCT strains compared to the control (pYUB28b). Results represent means ± SD from three biological replicates per experiment.

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