Fig. 3: Dynamic A/B compartment switch in the tumorigenesis and metastasis of colorectal carcinoma. | Communications Biology

Fig. 3: Dynamic A/B compartment switch in the tumorigenesis and metastasis of colorectal carcinoma.

From: 3D genome landscape of primary and metastatic colorectal carcinoma reveals the regulatory mechanism of tumorigenic and metastatic gene expression

Fig. 3

a Clustering heatmap of Hi-C PCA1 value in different samples. b Proportional distribution of A/B compartment switch in CRC-03 patient during the tumorigenesis and metastasis of colorectal carcinoma. c Compartment stability score in tumorigenesis or metastasis of patients with or without metastasis. *p ≤ 0.05, ns: no significance, Wilcox-test. d Box plot of PC1 changes of significantly downregulated and upregulated genes in colorectal cancer tumorigenesis. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001, ns: no significance, t-test. e Box plot of PC1 changes of significantly downregulated and upregulated genes in colorectal carcinoma metastasis. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001, ns: no significance, t-test. f Pearson correlation heatmap of chr5 in CRC-05-T and CRC-05-N samples. g Pearson correlation heatmap of chr5 in CRC-05-M and CRC-05-N samples.

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