Fig. 2: Human proteomic landscape of stool-derived extracellular vesicles.

A Total protein abundance for samples submitted for mass spectrometry (iBAQ values), Mean ± SD. B Number of human proteins detected for each sample, Mean ± SD. C Protein abundance (iBAQ) for each protein detected in larger cohort oriented by rank. D Percent of total protein abundance per protein detected in larger cohort oriented by rank. E Detection range for human proteins in the larger cohort of 63 stool EV samples. F String diagram depicting interactions of proteins identified in 75% or more of samples. G Enriched GO and KEGG processes among human proteins detected in 75% or more of samples in larger cohort. H Subcellular location for human proteins identified in the large cohort of 63 stool EV preparations. I Protein coverage among stool, urine, and plasma EV preparations.