Fig. 3: Genes with lower expression in monosomy X when compared to 46,XX or 46,XY controls.
From: The transcriptomic landscape of monosomy X (45,X) during early human fetal and placental development
a Five-way Venn diagram showing overlap of genes with lower expression in monosomy X when compared to control karyotypes across all tissues. b Graph to show genes with lower expression in monosomy X across all tissues with inset of violin plot showing normalized count data of SLC25A6 across all tissues (from panel a) according to karyotype (n = 4 in each group). Pseudoautosomal region (PAR) genes are shown in bold and dark bars. c Heatmap of SLC25A6 expression across all tissues used in study. d Schematic of the X chromosome and showing PAR1 and PAR2 genes. e Differential expression of genes located on the PAR regions for 45,X compared to 46,XX or 46,XY samples. Individual mean data points for each tissue group are shown, as indicated in the legend. The bars represent the mean of the different tissue groups with standard error of the mean shown. Log2 fold change (FC) = −1.0 represents half the expression in 45,X samples (i.e., haploinsufficiency), whereas log2FC = 0 represents similar expression in 45,X samples and 46,XX and 46,XY controls (n = 4 for each karyotype in each tissue group).
