Table 2 Genetic mutations in synthetic phages used in the search for the Tmn trigger
From: Phage engineering to overcome bacterial Tmn immunity in Dhillonvirus
Phage name | Sensitivity | Mutated gene | ||
|---|---|---|---|---|
CDS6 (nmad5) | CDS18 | CDS25 | ||
ΦSMS22Δanti-Tmn | Sensitive | |||
ΦSMS22Δanti-Tmn_em | Resistant | Lys296Glu | Pro59fs, Pro60-Ter66del | Asp1098fs, Gln1104fs |
ΦSMS22Δanti-Tmn_emNmad5C | Sensitive | Pro59fs, Pro60-Ter66del | Asp1098fs, Gln1104fs | |
ΦSMS22Δanti-Tmn_emCDS18C | Resistant | Lys296Glu | Asp1098fs, Gln1104fs | |
ΦSMS22Δanti-Tmn_emCDS25C | Resistant | Lys296Glu | Pro59fs, Pro60-Ter66del | |
