Table 1 E. coli clinical isolates with their MICs and AMR genotypes

From: Ribosome phenotypes for rapid classification of antibiotic-susceptible and resistant strains of Escherichia coli

E. coli Clinical Isolate

Ciprofloxacin MIC (mg/L)

Relevant genotype information

gyrA

marR

parC

parE

Susceptible 1 (S1)

0.015

   

I355T

Susceptible 2 (S2)

0.25

 

S3N

  

Susceptible 3 (S3)

0.25

   

I529L

Resistant 1 (R1)

2

D87Y, S83L

 

S80I

 

Resistant 2 (R2)

16

D87N, S83L

 

E84V, S80I

I529L

Resistant 3 (R3)

64

D87N, S83L

 

S80I

S458A

Resistant 4 (R4)

128

D87N, S83L

 

S80I

S458A

  1. Each clinical isolate used in this project is listed with its MIC and relevant genotype information. All strains are Escherichia coli isolated from bloodstream infections in the United Kingdom, obtained and whole-genome sequenced for a previous study57. MICs were determined by broth microdilution. (See Methods: Bacterial strains and sample preparation for details of MIC and sequencing methods).
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