Fig. 4: Accumulation curves for the pan/core-genomes/ resistance-genomes of mcr-carrying plasmids (pMCRs).

a Accumulation curves for the pan/core genomes of pMCRs belonging to four Inc types. Blue and red lines represent the number of pan and core genes in sample combinations, respectively. The blue and red dots represent the median number of genes. Median lines fit the power law equation y = kxγ, and γ > 0 indicated an open pan-genome. IncI2: n = 242; IncHI2: n = 216; IncX4: n = 163; IncP: n = 31. b Accumulation curves for the pan/core-resistance genome of IncHI2 pMCRs. Blue and red lines represent the number of pan and core-resistant genes in sample combinations, respectively. The blue and red dots represent the median number of genes. γ > 0 indicated an open pan-resistant genome.