Fig. 3: Candidate genes presenting eQTLs in putative adaptive genomic windows identified by the LASSI method and able to influence their expression in specific tissues. | Communications Biology

Fig. 3: Candidate genes presenting eQTLs in putative adaptive genomic windows identified by the LASSI method and able to influence their expression in specific tissues.

From: Convergent evolution of complex adaptive traits modulates angiogenesis in high-altitude Andean and Himalayan human populations

Fig. 3

Schematic representation of the body districts in which the expression of the COL4A1, IGF1R, PDGFD, ITGA8, RYR3, LAMC2, PLCE1 and PRKCE candidate adaptive genes is modulated by eQTLs annotated in the GTEx portal. Genes reported in bold/red are those previously proposed to play an adaptive a role also in populations of Tibetan/Sherpa ancestry52,60,62,65. Illustration from NIAID NIH BIOART Source (https://bioart.niaid.nih.gov/bioart/519; https://bioart.niaid.nih.gov/bioart/420).

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