Fig. 3: Functional programming of effector CD8 T cells in lungs of SARS-CoV-2 and influenza virus-infected mice.
From: Effector CD8 T cell differentiation in primary and breakthrough SARS-CoV-2 infection in mice
K18-ACE2tg mice were intranasally infected with either IAV or WU strain of SARS-CoV-2 viruses, and lung cells stained as described in Fig. 1. Lung cells from infected mice were stimulated with the S525 peptide of SARS-CoV-2 Spike (S) protein, or the NP366 peptide of IAV Nucleoprotein (NP). Cytokine production by CD8 T cells was assessed by intracellular cytokine staining. Percentages of cytokine-producing cells among the gated CD8 T cells are shown. Data represent four independent experiments. Data in each graph indicate mean ± SEM.
