Fig. 5: SIINFEKL-specific CD8 T cell responses following ADJ + CpG vaccination and CoV-OVA challenge.
From: Effector CD8 T cell differentiation in primary and breakthrough SARS-CoV-2 infection in mice
WT C57BL/6 mice were vaccinated with 5% Adjuplex plus 10 µg of CpG and 10 µg of OVA or NP protein via subcutaneous (SC) or intranasal (IN) routes, followed by challenge with CoV-OVA. Cohorts of mice were administered CD8 T cell depleting antibody by combined IV and IN routes. On day 5 post-challenge, lungs were collected for CD8 T cell and viral load analysis. Graphs show flow cytometric analysis of recall SIINFEKL-specific CD8 T cells, weight loss measurements, and quantification of lung viral loads. Data are representative of two experiments. Data in each graph indicate mean ± SEM.
