Table 1 Select somatic mutations present in cancer gene pathways in two organoids (F147T and F130T)
From: Comprehensive genomic dependency landscape of a human colon cancer organoid
Pathway | F147T | F130T |
|---|---|---|
WNT | RNF43:Gly659>fs | APC:Arg1450>Stop, Arg2347>Ser |
MAPK | BRAF:Val600Glu/HRAS:Gly12Asp | KRAS:Gly12Val |
PI3K | PTEN:Val93fs | PIK3CA:Asn319Tyr |
Mismatch Repair | MLH3:Gly981Ser/MSH3:Lys383fs | - |
