Fig. 2: Sequence and topology 2D alignment of N-term Ig-domains.
From: Unusual traits shape the architecture of the Ig ancestor molecule
2D sequence/topology alignments allow the integration of sequence and topological assembly into one single map and subsequent comparison of a series of diverse Ig sets. Shown are the 2D maps for a series of Ig-sets representative of the evolution of the Ig domain in the animal kingdom. Colors correspond to the Ig Protodomain reduced rainbow color spectrum41 with four strands colors blue, green, yellow, and orange for ABCC’ and DEFG and a fifth color red for the C” strand, if present. Using this color scheme, a sheet ABED will be blue-green-green-blue; a sheet GFCC’ will be orange-yellow-yellow-orange.
