Fig. 2: Inflammation outcomes in response to developmental PM2.5 exposure and OVA challenge. | Communications Biology

Fig. 2: Inflammation outcomes in response to developmental PM2.5 exposure and OVA challenge.

From: Developmental air pollution exposure augments airway hyperreactivity, alters transcriptome, and DNA methylation in female adult progeny

Fig. 2

Representative histological images A of H&E stained lung sections (black bar = 200 μm) from 13-week-old female (i) Sham, (ii) Sham-OVA, (iii) PM, and (iv) PM-OVA (n = 5–8 per treatment) offspring, quantified for peribronchiolar inflammation B presented as median ± range and analysed with Kruskal–Wallis test + Dunn’s multiple comparison test; *=p < 0.05; **=p < 0.01. Post-lung function testing BALF cellularity C–F assessed via differential cell counts (n = 5–9 per treatment). Data are presented as median ± range and analysed with a mixed-effects model with the Geisser–Greenhouse correction + Tukey’s post-hoc test for multiple comparisons; *=p < 0.05; **=p < 0.01 (C).

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