Fig. 7: LRRC19 may promote the restoration of tryptophan metabolic function in maternal high-fat diet offspring via shaping the gut microbiota. | Communications Biology

Fig. 7: LRRC19 may promote the restoration of tryptophan metabolic function in maternal high-fat diet offspring via shaping the gut microbiota.

From: Maternal high-fat diet disrupts intestinal mucus barrier of offspring by regulating gut immune receptor LRRC19

Fig. 7

A Relative abundance of indoles and amino acids producing by microbiota in the individual fecal samples among four groups. B, C Principal component scores were respectively shown as 2D plot (B) and 3D plot (C) (determined by unweighted UniFrac analysis). D Reliable metabolic markers were screened by volcano plot. Volcano plot comprehensively inspected the contribution of metabolites to the model group (Variable importance in the projection, VIP) and reliability of metabolites (the Correlation Coefficients, Corr. Coeffs). Metabolites that significantly increase in the MCD group are shown in green, while those significantly increase in the MHFD group are shown in red. E Levels of IAA among four groups were shown in the vioplot. F Z-Score of differential metabolites was shown as point plot and heatmap. MCD, maternal control diet. MHFD, maternal high-fat diet. WT, wild type (Lrrc19+/+). In MCD and MHFD groups, n = 5; In WT-MHFD and Lrrc19−/−-MHFD groups, n = 9. Bars indicated means ± SDs.

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