Fig. 1: RBPMS is expressed at lower levels in MIBC than in NMIBC. | Communications Biology

Fig. 1: RBPMS is expressed at lower levels in MIBC than in NMIBC.

From: RBPMS inhibits bladder cancer metastasis by downregulating MYC pathway through alternative splicing of ANKRD10

Fig. 1

a mRNA levels of RBPMS in BLCA (n = 188) and normal tissues (n = 68) in the GSE13507 cohort. b mRNA levels of RBPMS in MIBC (n = 38) and NMIBC (n = 93) in the GSE32548. c mRNA levels of RBPMS in MIBC (n = 93) and NMIBC (n = 213) in the GSE32894 cohorts. d mRNA levels of RBPMS in various T-stages of BLCA in the GSE32894 cohort. e Representative images of IHC staining of RBPMS in normal tissue, NMIBC and MIBC from tissue microarrays. f Functional enrichment analysis of proteins interacting with RBPMS (https://cn.string-db.org/). g Schematic representation of the four splice variants of RBPMS mRNA. Rectangles represent exons and colors represent coding sequence regions. “R-1/4,” “R-2,” and “R-3” arrows indicate the locations of RT-PCR primers for determining different isoforms expression. “R-T” arrows indicate the positions of qRT-PCR primers used to determine total RBPMS expression. h mRNA expression levels of four splice variants of RBPMS in the TCGA-BLCA cohort (n = 427). i mRNA expression levels of the four splice variants of RBPMS in BLCA cell lines were detected by qRT-PCR (n = 3). Data are shown as mean ± SD. The n number represents n biologically independent experiments in each group.

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