Fig. 6: RBPMS inhibits MYC transcription of target genes by AS of ANKRD10. | Communications Biology

Fig. 6: RBPMS inhibits MYC transcription of target genes by AS of ANKRD10.

From: RBPMS inhibits bladder cancer metastasis by downregulating MYC pathway through alternative splicing of ANKRD10

Fig. 6

Representative image (a) and cell counting histogram (b) of wound healing from the indicated groups with ANKRD10-2 knockdown in 5637 sgCtrl and sgRBPMS cells (n = 3). Representative image (c) and cell counting histogram (d) of transwell assays assays from the indicated groups with ANKRD10-2 knockdown in 5637 sgCtrl and sgRBPMS cells (n = 3). e After ANKRD10-2 knockdown, 5637 sgCtrl and sgRBPMS cells were transfected with an E-box dual-luciferase plasmid and assayed for reporter fluorescence activity (n = 3). f mRNA levels of MYC target genes in 5637 sgCtrl and sgRBPMS cells detected by qRT-PCR after ANKRD10-2 overexpression (n = 3). g Schematic showing the mechanism by which RBPMS inhibits BLCA migration and invasion via the RBPMS /ANKRD10/MYC axis. Data are shown as mean ± SD. The n number represents n biologically independent experiments in each group.

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