Fig. 2: Gbp5 is required for expansion of innate lymphoid cells (ILCs) in DSS-induced colitis. | Communications Biology

Fig. 2: Gbp5 is required for expansion of innate lymphoid cells (ILCs) in DSS-induced colitis.

From: STAT1 mediates the pro-inflammatory role of GBP5 in colitis

Fig. 2

a Counts of ILC1s, ILC2s and ILC3s in the colon of DSS-treated mice and control mice. Values are based on the total numbers of ILCs and the percent representations of each ILC. b Flow cytometry analysis of ILC1s (NKp46+RORγt-), ILC2s (KLRG1+RORγt-) and ILC3s (RORγt+) in the colons of DSS-treated mice and control mice. CD45+Lin- lymphocytes were gated out for analysis of ILCs. (Lin = CD3ε, CD45R/B220). Numbers denote percentage of cells inside the gate. c The expression levels of driver cytokines for ILCs and ILC markers in the colons of WT and Gbp5-/- mice on day 7 of DSS treatment, according to qRT-PCR analyses, normalized to that of ACTB. n = 3 biologically independent samples for each group. Data are mean ± SEM, Mann-Whitney U test.

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