Fig. 8: Anti-angiogenic activity of ORN 3 and ORN 4 G4s: inhibition of HUVEC tube formation and modulation of VE-cadherin expression. | Communications Biology

Fig. 8: Anti-angiogenic activity of ORN 3 and ORN 4 G4s: inhibition of HUVEC tube formation and modulation of VE-cadherin expression.

From: Unmodified RNA sequences form unusual stable G-quadruplexes with potential anti-RSV and anti-angiogenesis applications

Fig. 8

a ORN 3 and ORN 4 G4s inhibited the tube formation of HUVECs stimulated by VEGF. Scale bar: 250 μm (n = 3). b Western blot analyzed of VE-cadherin protein expression in HUVECs stimulated by VEGF and treated with ORN 3 and ORN 4 G4s (low dose 10 μM, high dose 20 μM), AS1411 (10 μM), mutORN 3, mutORN 4(20 μM). **P < 0.01 vs. control group; ##P < 0.01 vs. VEGF group (Student’s t-test) (n = 3).

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