Fig. 6: PTOV1 promotes tumor growth through ZNF449.
From: PTOV1 interacts with ZNF449 to promote colorectal cancer development
A Cell growth curve measured by CCK-8 assay between Vector, oePTOV1, si-NC, si-ZNF449#2, and oePTOV1+si-ZNF449#2. B PTOV1 overexpression promoted colony formation and the effect could be attenuated by knock downing ZNF449. C Transwell assays showing that PTOV1 overexpression promoted tumor cell invasion and the effect could be attenuated by knock downing ZNF449. The numbers of invading cells are shown. Bars: 50 μm. D Typical pictures of subcutaneous tumor between Vector, oePTOV1, si-NC, si-ZNF449#2, and oePTOV1+si-ZNF449#2. Bars: 50 μm. The means ± SDs are provided (n = 3). *P < 0.05, **P < 0.01, and ***P < 0.001 according to two-tailed Student t-tests or one-way ANOVA followed by Dunnett tests for multiple comparisons.
