Fig. 3: Chromatin accessibility profiles from joint snRNA-seq and snATAC-seq of the BWS and nonBWS livers. | Communications Biology

Fig. 3: Chromatin accessibility profiles from joint snRNA-seq and snATAC-seq of the BWS and nonBWS livers.

From: Single-nucleus multiomic analysis of Beckwith-Wiedemann syndrome liver reveals PPARA signaling enrichment and metabolic dysfunction

Fig. 3

The uniform manifold approximation and projection (UMAP) of BWS (n = 4) and nonBWS (n = 3) livers using snATAC-seq with cell annotation predicted from snRNA-seq dataset for BWS liver (a) and nonBWS liver (b). All 17 cell subpopulations representing major cell types in the liver are represented. Bar plot of annotated differentially accessible region (DAR) locations for each cell type in BWS liver (c) and nonBWS liver (d). e Heatmap showing transcription factor expression and group specificity of the eRegulon are displayed using SCENIC + . The activating eRegulons with calculated region-to-gene correlation coefficients (rho) bigger than 0.6 are included in the graph. Red: high normalized transcription factor expression; Blue: low normalized transcription factor expression.

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