Fig. 4: PPARA functionality testing in BWS patient hepatocytes. | Communications Biology

Fig. 4: PPARA functionality testing in BWS patient hepatocytes.

From: Single-nucleus multiomic analysis of Beckwith-Wiedemann syndrome liver reveals PPARA signaling enrichment and metabolic dysfunction

Fig. 4

a–c Top GO terms with highest fold change, (adjusted p value < 0.05) and enriched in the three hepatocytes clusters (Cluster 0, 1, 7) of BWS livers (n = 4) when compared to nonBWS (n = 3) livers were plotted. Processes in orange are known PPARA downstream functions. d–g Violin plots of gene expression categories PPARA tailored analysis, curated from34. Wilcoxon p values were all less than 0.05.

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