Fig. 1: The ML233 molecule exhibits no detectable toxicity on zebrafish embryos.
From: The small molecule ML233 is a direct inhibitor of tyrosinase function
A 2D representative structure of the ML233 chemical (molecular weight: 359.44). B Zebrafish embryo survival (% of viability) was quantified in non-treated, control (DMSO) and ML233-treated embryos by OECD236 test to assess acute toxicity in fish embryos (n ≥ 20). C Table showing the number of embryos used for the OECD236 test in (B) and the survival rate every day between 1 and 4 dpf. D Skin pigmentation of DMSO-, ML233-, arbutin-, or -kojic acid-treated embryos at 48 hpf after treatment between 4 and 48 hpf.
