Fig. 4: Inhibition of SCD enhances interferon signaling in macrophages and T cells and decreases T cell exhaustion in the TME. | Communications Biology

Fig. 4: Inhibition of SCD enhances interferon signaling in macrophages and T cells and decreases T cell exhaustion in the TME.

From: Targeting SCD triggers lipotoxicity of cancer cells and enhances anti-tumor immunity in breast cancer brain metastasis mouse models

Fig. 4

A UMAP of macrophages in control and SCDi-treated tumors. B Heatmap of the top 20 upregulated genes in the macrophage subclusters. C Histograms representing proportions of macrophage subpopulations in control and SCDi-treated tumors. D Pathway analysis (MSigDB) of the differentially expressed genes (DEGs) in macrophages (SCDi vs control). E Heatmap representing the DEGs belonging to the interferon alpha and gamma response pathways in macrophages (SCDi vs control). F UMAP of T cells in control and SCDi-treated tumors. G Violin plots showing the expression of cell type, activation, and exhaustion markers in the T cell subclusters. Cluster 0 represents activated cytotoxic T cells, cluster 1 represents T cells + macrophages, cluster 2 represents activated T helper cells, and cluster 3 represents exhausted T helper cells. H Histograms representing proportions of T cell subclusters in control and SCDi-treated tumors. I Pathway analysis (MSigDB) of the DEGs in T cells (SCDi vs control). J Heatmap representing a subset of relevant DEGs in T cells (SCDi vs control).

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